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The pandemic emphasized the urgent need to modernize and strengthen health services and public health surveillance, and it demonstrated that epidemic response systems are a key aspect of health systems’ resilience ( The widespread use of whole genome sequencing (WGS) to detect and characterize novel variants of SARS-CoV-2 has been instrumental in guiding the risk assessment and public health management of the COVID-19 pandemic at the local, national, and international levels ( Building upon an appraisal of the role played by WGS in detecting novel SARS-CoV-2 variants and monitoring viral spread, this article advocates for extended use of genomic surveillance in the risk assessment and mitigation of health threats from other infectious diseases and AMR